What diseases can be improved by stem cell therapy?
What diseases and conditions can regenerative medicine using the power of cells help?
What diseases can be improved by stem cell therapy?
Regenerative medicine and stem cell therapy are treatments that maximize the patient’s own “natural ability to repair and regenerate the body,” and are intended to “restore the natural healing power of organs whose functions have deteriorated,” which has not been possible with conventional drugs, etc., and have almost no side effects. It is a new treatment option for patients who have been unable to benefit from conventional therapies.
Typical diseases for which stem cell therapy has been shown to be effective in Japan and China so far include the following
Brain diseases: stroke, cerebral infarction, Alzheimer’s disease
It has been said that cranial neurons do not regenerate in the same way as cardiomyocytes. This is because cranial neurons and cardiomyocytes undergo little cell division after maturation. However, recent studies have shown that some cranial neurons and cardiomyocytes do regenerate. For example, it has been reported that some cranial neurons divide to generate new neurons. In order to regenerate, it is said that “appropriate environment and stimulation” are necessary, and in the absence of such environment and stimulation, regeneration may not occur. This “appropriate environment and stimuli” are rehabilitation therapy and the stem cells produce, cytokines, and exosomes.
Effective Nasal Inhalation Therapy at Home
In a normal IV infusion, most of the active components of the culture supernatant fluid are used to repair other cells in the body. In addition, there is a blood-brain barrier that prevents harmful substances and foreign substances from entering the brain. Cytokines and exosomes in culture supernatant fluid can easily break through the brain barrier due to their small molecular size. The active ingredients administered intranasally reach the brain via the nasal mucosa and nasal vascular network, and are used to repair nerve cells in the brain, resulting in recovery of the patient’s condition.
There was a case in which cough and sore throat caused by Covid-19 infection were alleviated and inflammation of the lungs recovered by inhaling stem cell culture supernatant fluid at home.
Advantages of Intranasal Stem Cell Culture Supernatant Administration
- Easy method: nasal administration is possible for patients and elderly patients who have difficulty attending clinics without special equipment or facilities, either by themselves or with the assistance of a family member
- Self-administration is possible: Intranasal administration allows patients to self-administer the medication themselves. This allows patients to administer medications according to their own schedule, such as their own rehabilitation therapy, thus improving the effectiveness of their treatment.
- Rapid absorption: Because the drug is absorbed directly through the nasal cavity, digestion and metabolism in the gastrointestinal tract can be avoided. The mucosa of the nasal cavity is very rich in blood vessels, which allows for rapid absorption of the drug, thus providing the advantage of a faster onset of effects.
In the case of recovery from cerebral infarction, improvement was seen when administered by nasal drip immediately after rehabilitation therapy. In the case of Alzheimer’s disease, the progression of the disease was halted, and many cases of improvement were also observed. For more rapid results, carotid injections can also be administered by a skilled physician.
Nervous system trophic factor (cytokine)
- CNTF (ciliary neurotrophic factor) Promotes proliferation and activity of neural stem cells
- GDNF (glial cell line-derived neurotrophic factor) Promotes neuronal differentiation and growth and dopamine uptake
- NGF (nerve growth factor) Synthesizes and promotes neurotransmitters, maintains nerve cells, repairs damaged cells, restores cranial nerve function, prevents Alzheimer’s disease and dementia
- BDNF (Brain-derived neurotrophic factor): Maintains nerve cell survival, promotes growth, prevents Alzheimer’s disease and dementia
- CNTF (ciliary neurotrophic factor): Promotes proliferation and activity of neural stem cells
- Interleukin-10: One of the inflammatory cytokines, which is believed to be involved in protecting nerve cells and suppressing neurodegenerative diseases.
Amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), Parkinson’s disease
Clinical Treatment Videos
Post stroke patient
Bone marrow-derived mesenchymal stem cells (BM-MSCs) and milk pulp-derived stem cells have shown improvement in disease progression. We are conducting clinical research on stem cell therapy for ALS and Parkinson’s disease at 369 Institute of Life Sciences of Zhongshan University, School of Life Sciences of Tsinghua University, and Institute of Regenerative Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, which are the most advanced life science research institutes in China.
Arteriosclerosis＆Hypertension
The following cytokines are known to be secreted by stem cells and their effects on the treatment of atherosclerosis and hypertension have been confirmed and there are numerous therapeutic examples.
- VEGF (vascular endothelial growth factor) VEGF is known to have therapeutic effects on atherosclerosis and hypertension by promoting new blood vessel formation.
- HGF (hepatocyte growth factor) HGF is involved in the repair of vascular damage by promoting the proliferation and regeneration of vascular endothelial cells.
- TGF-β (transforming growth factor-beta) TGF-β is believed to prevent the progression of atherosclerosis by controlling the proliferation of vascular smooth muscle cells.
- SDF-1 (stromal cell-derived factor-1) SDF-1 is involved in the differentiation and growth of vascular endothelial cells and vascular smooth muscle cells, and plays an important role in the repair of vascular damage.
- IL-10 (interleukin-10) IL-10 has an inhibitory effect on inflammation and has been reported to alleviate the inflammatory response involved in hypertension.
Diabetes & Rheumatoid Arthritis
- VEGF (vascular endothelial growth factor) VEGF is known to be effective in the treatment of ulcers and retinopathy in diabetic patients by promoting new blood vessel formation.
- HGF (hepatocyte growth factor) HGF is reported to be effective in the treatment of neuropathy and renal failure in diabetic patients by promoting cell proliferation and regeneration.
- G-CSF (granulocyte colony-stimulating factor) G-CSF is reported to be effective in the treatment of ulcers in diabetic patients by promoting proliferation and differentiation of hematopoietic stem cells.
- IL-6 (interleukin-6) IL-6 is known to be involved in the improvement of lipid metabolism and insulin sensitivity by promoting inflammatory responses.
- TGF-β (transforming growth factor-beta) TGF-β is believed to inhibit the progression of diabetes mellitus by suppressing the inflammatory response that is overproduced in diabetes.
The mechanism by which rheumatic pain is reduced by stem cell therapy involves mainly anti-inflammatory, immunomodulatory, and tissue repair/regeneration actions. These actions are modulated by cytokines and exosomes secreted by stem cells.
- Anti-inflammatory: Stem cells suppress the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, etc.) and promote the production of anti-inflammatory cytokines (IL-10, TGF-β, etc.), thereby reducing inflammation.
- Immunomodulatory action: Stem cells suppress autoimmune reactions by regulating the function of immune cells such as T cells, B cells, macrophages, and dendritic cells. This is expected to reduce inflammation and destruction of joints caused by rheumatoid arthritis.
- Tissue repair and regeneration: Stem cells secrete cytokines and growth factors that promote repair and regeneration of damaged tissues. This is thought to repair the destruction of joint tissue caused by rheumatoid arthritis and reduce pain.
Immune system boost and cancer prevention
NK cell, NKT cell, and dendritic cell therapy are available in Japanese clinics to boost immunity and prevent cancer.
NK cells are part of the innate immune system and can find and directly attack abnormal cells such as cancer cells and virus-infected cells. NK cells can also receive signals from dendritic cells and activate them more efficiently; IL-2 and IL-15, stem cell-derived cytokines, have been shown to be effective in activating NK cells.NKT cells are a type of immune system that has both innate and acquired immune functions; NKT cells can attack abnormal cells such as cancer cells and virus-infected cells. They can also receive signals from dendritic cells and activate them more efficiently; the stem cell-derived cytokines IL-2 and IL-12 have been shown to be effective in activating NKT cells.Dendritic cells are a type of antigen-presenting cell that can activate T and B cells. In dendritic cell therapy, the patient’s own dendritic cells are harvested, activated in vitro, and then returned to the patient to enhance the effectiveness of cancer treatment. The stem cell-derived cytokines GM-CSF and IL-4 have been shown to be effective in dendritic cell therapy.
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Infertility treatment
Infertility Treatment Cytokines, such as FGF2 (fibroblast growth factor 2), EGF (epidermal growth factor), and VEGF (vascular endothelial growth factor), are included in the stem cell culture supernatant solution. These components are believed to promote proliferation and differentiation of ovarian and endometrial cells and increase the thickness of the endometrium.Endometrial stem cells can be extracted from menstrual blood and cultured for treatment.
Back and knee pain, osteoarthritis Sarcopenia
Back and knee pain, osteoarthritis Sarcopenia Sports injuries, meniscus injuries Cytokines such as IL-1ra (interleukin-1 receptor antagonist), IL-10 (interleukin-10), and TGF-β (transforming growth factor-β) are believed to play important roles in the treatment of joint pain and osteoarthritis. These cytokines suppress inflammation in joints. These cytokines can inhibit inflammation in joints and promote tissue repair.
Cytokines such as IL-6 (interleukin-6) and IGF-1 (insulin-like growth factor-1) are also believed to play an important role in the treatment of muscle loss (sarcopenia). These cytokines can promote muscle growth and repair.In the treatment of sports injuries and meniscus injuries, cytokines such as IL-6, TGF-β, and PDGF (platelet-derived growth factor) are believed to play an important role. These cytokines can inhibit inflammation and promote tissue repair.The joint action of stem cells and culture supernatant fluid releases these cytokines, which can help improve conditions such as joint pain, muscle loss, sports injuries, and meniscus injuries.
The cure for this renowned professional athlete’s rapid improvement is regenerative medicine, stem cell therapy.
Jack Nicklaus, professional golfer
“I’m not a doctor, but I think that stem cell is going to change … the direction of orthopedics,” he says
To read more, check here “https://edition.cnn.com/2018/04/27/health/jack-nicklaus-stem-cell-therapy/index.html“
Skin & Hair Regeneration
Regeneration Cytokines such as epidermal growth factor (EGF), fibroblast growth factor (FGF), TGF-β, IL-6, and interleukin-8 (IL-8) play an important role in skin regeneration and wrinkle improvement. These cytokines promote cell growth and differentiation, suppress inflammation, and synthesize important components such as collagen and elastin, which can promote skin regeneration and wrinkle improvement.
On the other hand, cytokines such as VEGF (vascular endothelial growth factor), FGF-7, HGF (hepatocyte growth factor), and IGF-1 play an important role in hair regeneration. These cytokines can promote hair root growth and differentiation as well as stimulate papilla cells to promote hair growth.
Cataract, dry eye, presbyopia
Cataract, Dry Eye, Presbyopia In cataract, cytokines such as TGF-β, FGF-2, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) play an important role. These cytokines can inhibit cataract progression by promoting lens cell proliferation and differentiation.In presbyopia, cytokines such as FGF, IGF-1, and HGF play an important role. These cytokines can inhibit the progression of presbyopia by promoting the growth and repair of ocular tissues.
In dry eye, inflammatory cytokines such as IL-1, IL-6, and TNF-α are known to be increased. On the other hand, cytokines such as FGF-2, NGF, BDNF, and TGF-β have been reported to be deficient in tear fluid. These cytokines protect cells on the surface of the eye and promote tear film formation, thereby improving dry eye symptoms.
Culture supernatant fluid obtained from stem cells is known to contain these cytokines and is effective against cataracts, presbyopia, and dry eyes.
